Semaglutide, liraglutide, lixisenatide, dulaglutide, and tirzepatide are the current GLP1RAs available in Canada. These are approved for the treatment of type 2 diabetes and obesity and have been used ...

KEY POINTS Acute aortic syndrome (AAS) is a life-threatening emergency, accounting for 1/2000 presentations of acute chest or back pain to the emergency department. [1] [1] It is a clinical spectrum ...

An important flaw in the funding approach used by Canada’s public drug plans is highlighted by the findings of 2 articles related to the clinical value of direct oral anticoagulants (DOACs), published ...

Large inequities in virtually every measure of health and wellness exist between First Nations and their non-Indigenous counterparts. Efforts to improve First Nations’ health have been impeded by ...

Wernicke encephalopathy is a medical emergency with substantial morbidity and mortality A historical case series reported mortality in 17% of patients with acute Wernicke encephalopathy. 2 Of the ...

Since late 2023, new outbreaks have been reported in Bolivia, Brazil, Peru, and Cuba, including among travellers returning to Canada and the United States. [1] [1], [2] [2] Malaria, Zika, dengue, and ...

Pressurized metered-dose (pMDI) inhalers are an important contributor to greenhouse gas emissions Hydrofluorocarbon propellants in pMDIs are responsible for roughly 0.03% of yearly global greenhouse ...

Smoking marijuana can increase clearance of some drugs Smoked marijuana increases the clearance of theophylline 40%. 1 Similar findings would be expected for other drugs metabolized by CYP1A2, such as ...

Bupropion abuse is a growing public health problem Although bupropion shares some structural and pharmacologic properties with amphetamine, early research suggested the drug did not produce any ...

Staphylococcus aureus bacteremia is associated with substantial mortality and complications, including endocarditis and metastatic infection requiring specific investigations and treatment. [1] [1] ...

Marco L.A. Sivilotti, Mark C. Yarema and David N. Juurlink ...

Recreational use of nitrous oxide is a growing problem in many jurisdictions, including Canada. Although isolated, short-term use rarely leads to serious complications, chronic use can cause ...