Researchers report in the online edition of PNAS this week that they have discovered nearly 30 alternative splicing regulators in Drosophila —nearly triple the number previously known—using a novel ...

A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by ...

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. More than 90% of PDAC patients die within five years of diagnosis. Usually, by the time the cancer is identified, ...

Scientists at Università Cattolica reported on the discovery of a genetic mechanism that pancreatic cancer cells employ to evade treatment, and which the investigators say could pave the way to the ...

Researchers identify RBFox1 as a key intrinsic regulator of heart muscle cell maturation, overcoming a major limitation in cardiac regenerative therapy and disease modelling and demonstrating for the ...

CSHL’s Krainer lab used a technique called live-cell fluorescence imaging to observe the DDX23 enzyme (above, in green) in action. Together with the critical regulator protein SRSF1, DDX23 helps set ...

Mechanisms of molecular pathology and erythromycin treatment in myotonic dystrophy type 1 In myotonic dystrophy type 1, aberrant RNA transcribed from the mutant DMPK gene leads to the aggregation of ...

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes. These molecular machines snip extra bits out of our ...

Preclinical in vivo data demonstrate hyper-precise mechanism directly targets the disease-causing mRNA repeats leading to correction of splicing defects and reversal of myotonia Oral administration of ...

A team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, possibly leading to new therapies for heart disease and ...